A型肉毒毒素治疗Meige综合征及面部皮肤除皱临床研究

Botulinum Toxin Type A Therapy in Meige's Syndrome and Facial Wrinkles

目的观察A型肉毒毒素(BTXA)治疗Meige综合征及面部皮肤除皱的疗效,探讨降低药物副作用的发生及BTXA皮肤除皱的作用。方法对99例患者应用BTXA局部多点注射。结果治疗眼睑痉挛型、口下颌肌张力障碍型及眼睑痉挛并口下颌肌张力障碍型的显效率分别为98.4%、90.9%和95.8%。疗效持续时间分别为(16.9±8.4)周、(12.6±5.4)周和(13.5±5.7)周。面部皮肤除皱有效率100%,皮纹变浅、变平且光滑。局部副作用轻微、短暂且可自行消失。结论BTXA治疗Meige综合征及面部皮肤除皱疗效显著且安全性好。严格操作规程及掌握适当剂量能降低药物副作用的发生。

Objective To observe the efficacy of Botulinum toxin type A(BTXA)injection in Meige's syndrome and facial wrinkles and exp lore the method of reducing the side e ffect of BTXAand weaken facial wrink les.Methods Ninety-nine patients were evaluate d on the therapeutic efficacy of single and multiple topical facial in-jection with BTXA.Results The effective rates of patients with blepharospasm were 98.4%,oromandi bular dystonia 90.9%,blepharospasm and o romandibular dystonia 95.8%,respectively.The therapeutic effect for each disease lasted(16.9±8.4)weeks?(12.6±5.4)weeks and(13.5±5.7)weeks,respectively.Facial wrinkl es of all patients has got weakened and seemed much smooth and flattend.The rec overy rate approached to 100%.The local side effects were transient an d mild,and disappeared spontaneously.Conclusions The treatment of Meige's syndrome and facial wrinkles with BTXA could produce a significant impro vement,and is safe.Strictly observ e the procedures of injection,and use adequate dose of BTXA,the side effects o f BTXA can be decreased.