过度扩张对轴型皮瓣血运影响的实验研究

The influence of over-expansion on the blood supply of an axial-pattern flap

目的 探讨过度扩张对轴型皮瓣血运的影响。方法 以猪臀部双侧以旋髂深血管为蒂的岛状皮瓣分别作为实验组和自身对照组 ,观察过度扩张后岛状皮瓣成活、激光多普勒微区血流、荧光染色、组织丙二醛含量的变化 ,并用组织学检查和血管灌注透明标本显示其血管结构及构筑的变化。结果 过度扩张后岛状皮瓣远段的血运显著降低 ,轴型血管血管网有损伤表现、分布模式改变和长宽比例缩小。结论 过度扩张可影响轴型皮瓣的血运。

Objective\ To investigate the influence of over expansion on the viability and vascularity of an axial pattern flap. Methods\ Tissue expanders were implanted subcutaneously on the buttock of the mini pig. After over expansion, an axial pattern over expanded skin flap was elevated in the pig of the experimental group. The differences in flap survival, LDF, MDA content and fluorescein stain were observed between the control and the experimental groups. The vascular architecture changes were also recorded using histological and clearing specimen examination. Results\ The microcirculation in the distal segment of the axial flap was significantly weakened after over expansion. There were injury manifestation, change in vessel distribution and reduction of vascular territory in the axial over expanded flap. Conclusions\ Over expansion could cause chronic injuries to the axial vessel network and damage the blood supply of the axial pattern flap.\;