尿毒症患者血液透析前后血清免疫球蛋白及C_3的变化及意义

The Changes and Significance of the Serum Levels of Ig and G_3 in Uremia Patients Receiving Hemodialysis

目的:研究尿毒症患者血液透析前后血清免疫球蛋白(Ig)和C_3的变化与临床意义。方法:本研究对68名(18～59岁)尿毒症患者血液透析前后留取了血液标本检测免疫球蛋白和C_3。结果:血液透析后Bun和Scr下降,CO_2CP、IgG和C_3上升(P<0.01),IgA、IgM的变化无统计学意义。结论:尿毒症合并对机体不利的免疫损害,血液透析能明显改善尿毒症的症状,增强尿毒症患者的免疫功能。

Objective: To investigate the changes and clinical significance of serum levels of Ig and C3 before and after hemodialysis in patients with uremia. Methods: Sixty - eight patients with uremia were included in the study. Blood samples were collected before and after hemodialysis to examine Ig and C3. Results: After hemodialysis,Bun,and Scr,decreased significantly (P<0.01) .CO2CP, IgG and C3 increased significantly (P < 0.01) . NO significant change was observed in serum IgA and IgM. Conclusion : Uremia may be associated with immune damage, which has a disadvantageous effect. Hemodialysis can improve uremia symptoms apparently and enhance the immune function in patients with uremia.