Evidence for a mouse brain-specific variant of α-tubulin

While studying the neural precursor cell intermediatefilament protein known as nestin in the developing mousebrain, we observed a strong cross-reaction of our nestin antibody with a 50 kDa protein that appeared on embryonicday 10 and continued to accumulate until postnatal day 1.Here we report evidence that this protein is a brain-specificvariant form of or-tubulin and discuss its implications.