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格列维克的构效关系研究 被引量：1

Research on the relationship between structures and bio-activities of gleevec
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摘要 目的研究小分子有机生物碱类药物格列维克的三维结构与生理活性之间的关系。方法设计了一种表达格列维克及衍生物三维结构的方法。结果论证了三维结构与其生理活性之间的关系。结论甲基或低级烷基的引入导致了高选择性 ,使其活性增大。 Aim To research the relationship between the 3D structures and bio activities of gleevec.Methods A method to express the 3 D structures of gleevec and its derivatives was designed.Results Having demonstrated the relationship between the 3 D structures and bio activity of gleevec and its derivatives.Conclusion Introducing the methyl group or a low alkyl group resulting in the high selectivity and increase of its activity.
作者 蔡阳 欧阳荔
机构地区 北京大学药学院应用药物研究所 北京大学公共卫生学院中心仪器室
出处 《中国药物化学杂志》 CAS CSCD 2002年第5期276-278,共3页 Chinese Journal of Medicinal Chemistry
关键词 格列维克 慢性粒细胞白血病 生理活性 三维结构 gleevec CML bio activity 3D structure
分类号 R914 [医药卫生—药物化学]
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参考文献4

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同被引文献33

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中国药物化学杂志
2002年 第5期

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