期刊文献+

甾体类芳香酶抑制剂的构效关系与研究进展

Structure activity relationship and the research progress of steroidal aromatase inhibitors
下载PDF
导出
摘要 芳香酶是研究抗乳腺癌药物的新靶酶。本文从作用机制。 Aromatase is a new target enzyme for designing anti breast cancer drugs.The research progress of steroidal aromatase inhibitors in the mechanism and structure activity relationship were reviewed.
机构地区 复旦大学化学系
出处 《中国药物化学杂志》 CAS CSCD 2002年第5期298-304,共7页 Chinese Journal of Medicinal Chemistry
关键词 甾体类芳香酶抑制剂 构效关系 研究进展 抗癌药 抗乳腺癌药物 aromatase steroidal aromatase inhibitor anti breast cancer drug structure activity relationship
  • 相关文献

参考文献32

  • 1Oh SS,Robinson CH.Mechanism of human placental aromatase:A new active site model[J].J Steroid Biochem Mole Biol,1993,44(4-6):389-397.
  • 2Brueggemeier RW,Floyd EE,Counsell RE.Synthesis and biochemical evaluation of inhibitors of estrogen Biosynthesis[J].J Med Chem,1978,21(10):1007-1011.
  • 3Numazawa M,Tachibana M.A-or B-ring-substitated derivatives of androst-4-ene-3,6,17-trione as aromatase inhibitors.Structure-activity relation-ships[J].Steroids,1994,59(10):579-585.
  • 4Korzekwa KR,Trager WF,Smith SJ,et al.Theoretical studies on the mechanism of conversion of androgens to estrogens by aromatase[J].Biochem,1991,30(25):6155-6162.
  • 5Nishino Y,Scheider MR,Michna H.Antitumor effect of specific aromatase inhibitor:1-methyl-androsta-1,4-diene-3,17-dione (atamestane),in female rats bearing DMBA-induced mammary tumors[J].J Steroid Biochem,1989,34(1-6):435-441.
  • 6Miyairis S,Fishman J.3-Mthylene-substituted androgens as novel aromatization inhibitors.Evidence of a requirement for C-3 oxygen in C-19 hydroxylations[J].J Biol Chem,1986,261(15):6772-6777.
  • 719-Oxygenation of C19-steroids with an A,B-ring enone structure competitive inhibitors of estrogen biosynthesis,with human placental aromatase[J].Bio Pharm Bull,2001,24(4):332-335.
  • 8Wiseman LR,Mctavish D.Foremestane.a review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the management of breast cancer and prostatic cancer[J].Drugs,1993,45(1):66-84.
  • 9Di Salle E,Giudici D,Orati G.4-Aminoandrostenedione derivatives:a novel class of irreversible aromatase inhibitors.Comparision with FCF 24304 and 4-hydroxyandrostenedione[J].J Steroid Biochem Mol Biol,1990,37(3):369-372.
  • 10Abul-Hajj,Yusaf J.Aromatase inhibition by 4-thiosubstituted-4-androstone-3,17-dione derivatives[J].J Steroid Biochem,1990,35(1-3):139-143.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部