酸性粘多糖影响草酸钙结石形成的研究进展

Research progress in the effects of glycosaminogloycans on the formation of calcium oxalate calculus

泌尿系结石中 70 %以上为草酸钙 (CaOx)结石 ,体内CaOx结石的形成与CaOx晶体形成的热力学 (过饱和度 )和动力学 (成核、生长和聚集 )性质相关。尿液中存在的酸性粘多糖 (GAGs)对CaOx结石形成具有明显的抑制作用 ,不但能抑制CaOx晶体的成核、生长和聚集 ,而且能抑制其与尿路粘膜的粘附过程。本文综述了 8种内源性GAGs和部分外源性GAGs对CaOx结石形成影响的研究进展 ,期望GAGs能在临床上用来预防和治疗CaOx结石。

Above 70 percent of the urinary calculi was calcium oxalate (CaOx) calculus.The formation of CaOx calculus in vivo depended on the thermoynamics relating to supersaturation of CaOx and the kinetics relating to nucleation,growth and aggregation of CaOx crystals.Glycosaminogloycans existing in the urine had significant inhibitory effects on the formation of CaOx calculus.It was found in vitro that glycosaminogloycans could inhibit the nucleation,growth,aggregation and the adherence of CaOx crystals on the cellular surface of the urinary tract.The inhibition mechanisms in different processes differed from each other.In this paper the progress of the inhibition of 8 kinds of intrinsic GAGs and some extrinsic GAGs to the formation of CaOx calculus was summarized.It was expected that GAGs could be used to prevent and cure CaOx calculus in clinic.