肿瘤新生血管形成对无转移大肠癌预后判断的价值

Value of tumor angiogenesis for the prognosis of patients suffering from colorectal carcinoma without metastasis at the time of laparotomy

目的探讨肿瘤新生血管形成在无转移大肠癌预后判断中的价值。方法采用鼠抗人第八因子相关抗原单克隆抗体的免疫组织化学ABC法 ,对 5 8例无转移大肠癌手术切除标本中微血管进行定量检测。计数 2 0 0倍视野下 3个最高血管密度区的微血管数 (MVC) ,取其均数。结果MVC与无转移大肠癌术后复发 (P <0 0 5 )及肝转移 (P <0 0 1)有关 ,当MVC值大于 2 1时 ,发生肝转移及局部复发的风险极大 ;MVC与患者预后 (P <0 0 1)有关 ,当MVC值大于 11时 ,5年内死亡的风险显著增加 ,MVC值大于 2 1时 ,所有患者 5年内死亡。结论大肠癌组织内的MVC在无转移大肠癌术后局部复发、肝转移及预后判断中具有重大意义 。

ObjectiveTo determine the prognostic value of angiogenesis in non-metastatic colorectal carcinoma at the time of laparotomy.Methods Microvessel counts(MVC) of 58 specimens were investigated by immunohistological staining with a monoclonal antibody against F-Ⅷ RAg. Correlation between MVC, clinicopathologic factors, postoperative local recurrence, and liver metastasis was evaluated.Results MVC correlated positively with postoperative local recurrence(P<0 05) and liver metastasis(P<0 01).In cases of MVC>21, the risk of liver metastasis and local recurrence significantly increased. MVC also correlated with prognosis (P<0 01), all patients died within five years when the number of MVC was more than 21.Conclusion Angiogenesis within non-metastatic colorectal cancer is an indicator of tumor behavior and may identify patients at higher risk for local recurrence?liver metastasis and poor prognosis