败血症时甲状腺激素对肠屏障保护作用的研究

Effects of exogenous thyroid hormone on intestinal barrier in sepsis

目的研究败血症时甲状腺激素的代谢异常与肠屏障破坏之间的关系 ,探讨补充外源性三碘甲状腺原氨酸 (T3 )对败血症时肠屏障的保护作用。方法对 5 3只SD大鼠采用盲肠结扎打孔法制作大鼠败血症模型 ,并予以T3 (15 μg/kg)纠正败血症大鼠的低T3 状态。结果败血症组大鼠血清中游离T3 、游离T4 浓度与小肠组织中丙二醛含量呈明显的负相关 (P <0 0 5 )。治疗组大鼠肠屏障的破坏程度明显轻于败血症组。结论败血症时血清甲状腺激素的代谢异常与肠屏障的氧化损伤程度之间具有明显的相关关系。补充外源性甲状腺激素可以明显地保护肠屏障 。

ObjectiveTo investigate the relationship between metabolic abnormalies of thyroid hormone and intestinal barrier disfunction and the potential protective effects of exogenous thyroid hormone in sepsis. MethodsMurine septic model was established through cecal ligation puncture. Triiodothyronine (15?μg/kg) was given to the septic rats to correct the low T 3 syndrome. ResultsThere was significant negative correlation between the seral concentration of free T 3 or free T 4 and MDA concentration in the tissues of small intestines. The insulting degree of the intestinal barrier in the treatment group were much milder than that of the sepsis group. ConclusionsThere were significant correlation between the metabolic abnormalies of thyroid hormone and the oxic insults of the intestinal barriers in sepsis. Providing the thyroid hormone for the septic rats could protect the intestinal barriers and improve the prognosis of sepsis.