结直肠癌局限性肝转移的治疗

Treatments of Colorectal Cancer with Hepatic Localized Metastasis

[目的]探讨结直肠癌局限性肝转移多种治疗方法的价值。[方法]对我院1987年-2000年收治的原发癌根治术后的引例结直肠癌局限性肝转移患者进行回顾性研究。[结果]原发癌加肝转移灶切除患者1、3、5年生存率分别为85.7％、46.9％、32.1％,而肝转移灶未治疗的患者分别为26.7％、0、0,两者的差异均有显著性（P<0.05）;肝转移灶微波固化和无水酒精注射及肝脏区域化疗合并组患者1、3、5年生存率分别为 74.2％、42.9％、19.2％,其与肝转移灶切除组的差异均无显著性（P>0.05）,与肝转移灶未治疗组的1、3年生存率差异有显著性（P<0.05）。[结论]1结直肠癌局限性肝转移患者,应尽可能彻底切除原发癌和肝转移灶,肝转移灶微波固化和无水酒精注射及肝脏区域化疗是其治疗的重要补充。

[Purpose] To explore the effect of treatments of colorectal caneer with hepatic localized metastasis. [Methods] We conducted a retrospective analysis for 81 cases with primary cancer resected from 1987 to 2000 in our hospital. [Results]The 1-,3-,5-year survival rates were 85.7% ,46.9% ,32.1% in the group of resection of metastatic liver cancer,and 26.7% ,0,0 of the group of no treatment with metastatic liver cancer respectively(P < 0.05) .The 1-,3-,5-year survival rates were 74.2% ,42.9% , 19.2% respectively in the group of percutaneous ethanol injection (PEI), microwave coagulation treatment (MCT) and hepatic regional chemotherapy. There was no statistical difference between these groups and the resection group (P > 0.05}, and statistical difference between these groups and the no treatment group in the 1-, 3-year survival rates (P < 0.05). [Conclusion] We should resect primary and metastatic tumor in colorectal cancer with hepatic localized metastasis. PEI and MCT and hepatic regional chemotherapy play significant role to these patients.