摘要
米非司酮具有孕激素受体(PR)和糖皮质激素受体拮抗剂的作用。近年来米非司酮抗肿瘤作用受到重视。研究表明其在子宫平滑肌瘤治疗中是很有前途的药物之一。现就米非司酮治疗子宫平滑肌瘤的临床应用及其机理加以综述。
出处
《国外医学(妇产科学分册)》
CAS
2002年第5期299-301,共3页
Foreign Medical Sciences(Obstet Gynecol Fascicle)
参考文献18
-
1Koide SS.Mifepristone,Auxiliary therapeutic use in cancer and related disorders.J Reprod Med,1998,43(7):551-560
-
2Mahajan DK,London SN.Mifepristone (RU486) a review.Fertil Steril,1997,68(6):967-976
-
3Jang GR,Benet LZ.Antiprogestin pharmacodynmics,pharmacokinetics,and metabolism:implication for their longterm use.J Pharmacokinet Biopharm,1997,25(6):647-672
-
4Rein MS,Barbieri RL,Friedman AJ.Progesterone:A critical role in the pathogenesis of uterine myomas.Am J Obstet Gynecol,1995,172:14-18
-
5Maruo T,Matsuo H,Samoto T.Effects of P on uterine leiomy oma growth and apoptosis.Steroids,2000,65(10-11):585-592
-
6Rauk PN,Surti U,Roberts JM.Mitogenic effect of basic fibroblast growth factors and estradiol on cultured human myometrial and leiomyomas cells.Am J Obstet Gynecol,1995,173:571-577
-
7Wu X,Blanck A,Olovsson M,et al.Expression of basic fi broblast growth factor (b-FGF),FGF receptorl and FGF receptor2 in uterine leiomyomas and myometrium during the menstrual cycle,after menopause and GnRHa treatment.Acta Obstet Gynecol Scand,2001,80(6):497-504
-
8Chegini N,Tang XM,Ma C.Regulation of transforming growth factor-β1 expression by granulocyte macrophagecolony-stimulating factor in leiomyoma and myometrial smooth muscle cells.J Clin Endocrinol Metab,1999,84(11):4138-4143
-
9Lee BS,Nowak RA.Human leiomyoma smooth muscle cells show increase expression of TGFβ 3 and altered response to the antiproliferative effects of TGF-β.J Clin Endocrinol Metab,2001,86(2):913-920
-
10Arici A,Sozen I.Transforming gowth factor-β3 is expressed at high levels in the leiomyoma where it stimulates fibronectin expression and cell proliferation.Fertil Steril,2000,73(5):1006-1011
-
1吴洁丽,林毅,朱雪琼,吕杰强.米非司酮在子宫肌瘤中研究进展[J].国际生殖健康/计划生育杂志,2008,27(3):189-192. 被引量:22
-
2张蕾,陈忠东.米非司酮在妇科肿瘤治疗中的分子研究[J].美国中华临床医学杂志,2005,7(3):277-279.
-
3李春娇,黎文清.米非司酮在妇科肿瘤治疗中的研究进展[J].国际医药卫生导报,2006,12(8):119-121. 被引量:2
-
4徐明娟,方国恩,崔英,宋亮年,王昭梅.地塞米松对人卵巢癌细胞糖皮质激素受体的调节[J].上海医学,2003,26(1):53-55. 被引量:4
-
5夏冰,卢建,陈玉霞,王钢,陈光椿.地塞米松抑制卵巢癌HO-8910细胞增殖机制的研究[J].广东医学,2002,23(7):678-680.
-
6贺碧霞,乔丽云,彭军,谢治平,丁启龙.米非司酮对胰岛素抵抗的HepG_2细胞的作用及其机制(英文)[J].中国药科大学学报,2011,42(2):153-159.
-
7徐明娟,崔英,王昭梅,宋亮年.甾体激素对人卵巢癌细胞系3AO增殖分化的影响[J].上海医学,2001,24(2):99-101. 被引量:2