高血压病血瘀证与非血瘀证患者血清瘦素水平的比较

Comparison of Serum Leptin between Hypertensive Patients with Blood Stasis Syndrome Type and Non blood Stasis Syndrome Type

目的 :研究高血压病血瘀证与非血瘀证患者血清瘦素水平的变化及意义。方法 :采用放射免疫法测定 87例高血压病血瘀证与 114例高血压病非血瘀证患者的血清瘦素水平 ,观察其与性别、年龄、体重指数 (BMI)、脂肪百分比 (Fat% )、空腹血糖 (FBS)、总胆固醇 (TC)、高密度脂蛋白胆固醇 (HDL C)、低密度脂蛋白胆固醇 (LDL C)、甘油三酯 (TG)、内皮素 (ET)、血浆胰岛素 (INS)等指标的关系。结果 :血瘀证与非血瘀证患者BMI、INS、ET三项指标差异显著 (P <0 0 5和P <0 0 1) ;多元线性相关结果显示瘦素与ET呈负相关 ;在逐步回归分析中只有ET最后进入方程。结论 :高血压病血瘀证与非血瘀证患者的血清瘦素水平变化不大 ;ET是与血清瘦素水平变化的主要相关因素。

Objective: To study the change and significance of serum leptin in hypertensive patients with blood stasis Syndrome (BSS ) and non BSS types. Methods: Serum leptin was determined in 87 hypertensive patients with BSS type and 114 with non BSS type by radioimmunoassay, to observe its relationship with sex, age, body weight index (BWI), percent of fat (% FAT), fasting blood sugar (FBS), totoal cholesterol (TC), high and low density lipoprotein cholesterol (HDL C and LDL C), triglyceride (TG), endothelin (ET) and plasma insulin (INS). Results: Levels of BWI, INS and ET were different significantly between patients of BSS and non BSS (P<0 01 or P<0 05). Negative correlation was shown between leptin and ET by multivariance linear correlation analysis. Only ET entered in the regression equation. Conclusion: No significant difference of leptin level was shown in hypertensive patients of BSS and non BSS type, ET is the main factor that correlated with the change of leptin level.