OSAS患者循环ICAM-1,VCAM-1及L-选择素水平与心血管疾病的研究

RELATIONSHIP BETWEEN LEVELS OF CIRCULATING ICAM-1, VCAM-1,L-SELECTION AND CARDIOVASCULAR DISEASES WITH OSAS

目的 :探讨阻塞性睡眠呼吸暂停综合征 (OSAS)患者循环细胞间黏附分子 - 1(intercellularadhesionmolecule 1,ICAM - 1)、血管细胞黏附分子 - 1(vasculaecelladhesionmolecule 1,VCAM -l)及L -选择素 (L -selection)水平及与心血管疾病的相关性。方法 :选取OSAS患者 12例 (男性 9例 ,女性 3例 ,平均年龄 5 1.6±4 .8岁 )及 12例年龄相匹配的健康对照者。采用ELISA法检测OSAS患者入睡前、睡醒后血浆ICAM - 1、VCAM - 1及L -选择素水平 ,并与正常对照组比较。结果 :OSAS患者入睡前ICAM - 1,VCAM - 1及L -选择素水平较正常对照组升高 (ICAM - 1:4 0 2 .8± 4 8.2vs 2 0 8.4± 5 6 ,P <0 .0 5 ;VCAM - 1:814± 88.9vs 5 82±4 4 .5 ,P <0 .0 5 ;L -选择素 :1390 .4± 76 .8vs 10 4 4 .3± 80 .2 ,P <0 .0 1) ,睡醒后ICAM - 1及L -选择素水平较正常对照组明显升高 (ICAM - 1:395± 4 5vs 2 0 5± 5 0 ,P <0 .0 5 ;L -选择素 :114 3.5± 196 .2vs 10 2 5 .6±5 0 .3,(P <0 .0 5 )。结论 :OSAS所致的低氧血症激活了循环黏附分子 ,参与了心血管疾病的发生与发展。

Objective:To explore the relationship between levels of circulating Intercellular adhesion molecule 1(ICAM-1),Vascular cell adhesion molecule 1(VCAM-1) and L-selection and cardiovascular diseases with Obstructive sleep apnea syndrome(OSAS).Methods:The concentrations of ICAM-1,VCAM-1 and L-selection were measured in the serum by the ELISA method before and after sleep in 12 with OSAS and 12 age-matched controls.Results:The circulating ICAM-1,VCAM-1,and L-selection levels increased in the OSAS patients before sleep compared with the normal subjects(ICAM-1:402.8 ± 48.2 vs.208.4 ± 56 ng/ml,P<0.05;VCAM-1:814 ± 88.9 vs.582 ±44.5ng/ml,P<0.05);L-selection:1390.4 ± 76.8vs.1044.3 ±80.2ug/m,P< 0.01;after sleep, significantly higher levels of ICAM-1 and L-selection were observed in the OSAS group (ICAM-1: 395 ± 45vs.205 ±50,P<0.05;L-selection:1143.5 ±196.2vs.1025.6±50.3,P<0.05). Conclusions: OSAS-induced hypoxia activates adhesion molecules, resulting in the important risk factor of cardiovascular disorders.