急性胰腺炎血浆凝血功能检测对全身炎症反应综合征的临床意义

Clinic values of detecting blood coagulate function and systemic inflammatory response syndrom in acute pancreatitis patients

目的 探讨全身炎症反应综合征 (SIRS)和血浆凝血功能检测对 14 6例急性胰腺炎 (AP)患者多器官功能障碍综合征 (MODS)发生的预测意义。方法 用全自动血凝分析仪检测AP患者血浆PT、INR、APTT和FIB值。结果 SIRS患病率和血浆PT、INR、APTT和FIB值在MODS组和无MODS组间有显著性差异 (P <0 0 1) ;SIRS患病率为 5 0 7%,SIRS患者中MODS患病率为 32 4 %;SIRS和INRLogistic回归分析有显著意义 ,回归方程回代正确率为 91 1%。结论 单用SIRS预测AP患者MODS发生临床价值不大 ,而用SIRS和INR预测MODS发生有重要临床意义。

Objective To explore the values of systemic inflammatory response syndrom(SIRS) and detecting blood coagulate function to prognosticate MODS in acute pancreatitis patients.Methods Prothrombin time (PT),international normalized ratio(INR),actived partial thromboplastin time (APTT) and Fibrinogen of 146 cases of patients with AP were detected by full-automatic blood coagulation analyzer.Result The morbidity of SIRS and the date of PT?INR?APTT and FIB were significant difference between MODS group and no MODS group (P<0 01) The morbidity of SIRS was 50 7%,the morbidity of MODS was 32 4% in patients with SIRS;SIRS and INR were significant difference by logistic regression analyzing (P<0 01),and get a regression equation,the correct percentage of prediction was 91 1% Conclusion The clinic value of SIRS to prognosticate MODS was limited,but there was significant marketly for SIRS and INR to prognosticate MODS