阿莫西林钠舒巴坦钠与其它4种抗菌药物的体外抗菌活性比较

The study on antibacterial activity of amoxicillin sulbactam compared with other four antimicrobial agents in vitro

目的 比较研究阿莫西林舒巴坦 (amoxicillinsulbactam)与阿莫西林克拉维酸钾、阿莫西林钠、头孢噻肟、氨苄西林舒巴坦 4种抗菌药物的体外抗菌活性。方法 对 12 1株临床分离菌株 (经VITEK全自动微生物分析仪重新鉴定 ) ,采用琼脂平板二倍稀释法测定最低抑菌浓度 (MIC)。结果 阿莫西林舒巴坦对革兰阳性球菌的敏感率为 90 .91% ,明显高于阿莫西林和头孢噻肟 ,而对革兰阴性杆菌中大肠埃希菌、肺炎克雷伯菌、嗜血杆菌属的敏感率分别为 82 .35 %、83.3%和 10 0 % ,与阿莫西林克拉维酸、氨苄西林舒巴坦和头孢噻肟相近 ,明显高于阿莫西林。对不动杆菌敏感率为 83.33% ,显著高于阿莫西林 ,略强于其他两种酶抑制剂复合制剂和头孢噻肟 ;阿莫西林舒巴坦对临床常见产 β -内酰胺酶菌也显示了较高的抗菌活性。 结论 阿莫西林舒巴坦是一对临床常见致病菌尤其对不动杆菌抗菌作用较强的酶抑制复合制剂 。

Aim To evaluate the antibacterial activity of Amoxicillin sulbactam compared with other four antimicrobial agents in vitro.Methods Amoxicillin sulbactam against clinical isolated strains were compared with amoxicillin,ampicillin sulbactam ,amoxicillin clavulanic acid and cefetaxime.Minimal Inhibitory Concentrations (MIC) were determined by use of agar dilution method.Results The susceptible rate of amoxicillin sulbactam against gram positive ball strains was 90.91%,higher than those of amoxicillin and cefetaxime.The susceptible rate of amoxicillin sulbactam against E.coli,Klebsiella pneumoniae and Hamophilas influenzae was 82.35% 83.3% and 100%,similar with those of amoxicillin clavulanic acid,ampicillin sulbactam and cefetaxime,higher than that of amoxicillin.The susceptible rate of amoxicillin sulbactam against Acinetobacter was 83.33%,higher than that of amoxicillin significantly,and better than other two agents containing β-lactamases inhibitors and cefetaxime.The antibacterial activity of amoxicillin sulbactam against common clinical isolates was better than that of amoxicillin,especially to β-lactamases positive strains.Conclusion Amoxicillin sulbactam is an effective antibiotic containing β-lactamases inhibitor and a powerful antimicrobial agents for clinical bacterial infection,especially to Acinetobacter.