LIM蛋白家族的研究进展

A Review of the Research Progress on LIM Protein Family

LIM蛋白是分子结构中含有一个或多个LIM结构域的蛋白质家族,该家族中的蛋白质通过其LIM结构域与某些结构蛋白、激酶、转录调控因子等多种蛋白质相互作用,对某些基因的表达、细胞分化与发育、细胞骨架形成等发挥重要调控作用。本文介绍LIM蛋白家族的分类与功能、LIM蛋白及其与其他蛋白之间的相互作用,以及LIM蛋白在心血管系统中的作用。

LIM Proteins contain one or more LIM domains. Proteins of this family capable of interacting with many types of proteins have been identified including structural protein, kinase, and several classes of transcription factors. These interactions have been discovered to display important roles in a variety of fundamental processes including transcriptional regulation, development of cell types and organization of the cytoskeleton. This article reviews recent advances in the characterization of members of the LIM protein family, their biology roles, LIM domain binding protein and the function in heart development.