牙源性肿瘤中骨形成蛋白分布的免疫组织化学分析

Analysis of Distribution of BMP in Odontogenic Tumors

本文利用骨形成蛋白(BMP)单克隆抗体,采用免疫组化方法分析了7种25例牙源性肿瘤的 BMP分布。结果发现,根据有无 BMP,牙源性肿瘤可以分为两类:化牙骨质纤维瘤、良性牙骨质母细胞瘤、牙本质瘤、组合性牙瘤舍有丰富的 BMP;而造釉细胞瘤、牙源性腺样瘤、牙源性钙化上皮瘤则不含 BMP.BMP 与病理性牙齿硬组织同时存在,可能与牙源性肿瘤中硬组织的形成有关。各类牙源性肿瘤中 BMP抗原表达不一,可能是由于这些肿瘤发生于牙胚发育的不同阶段所致。

Distribution of BMP(bone morphogenetic protein)in odontogenic tumors wasanalysed using monoclonal antibody against BNP(BMP-McAb).Seven kinds of odon-togenic tumors(25cases)were studied,they included cementifying fibroma(8 cases),benign cementoblastoma(5 cases),dentioma(3 cases),compound odontoma(2 cases), amelobltoma(3 cases),adenomatoid odontogenic tumor(2 cases),calcifying epithelialodontogenic tumor(2 cases).The result showed that according to BMP,odontogenictumors could be divided into two types:all of cementifying fibroma,benign cementobl-astoma,dentioma,and compound odontoma demonstrated positive staining of BMP-McAb;all of ameloblastoma,adenomatoid odontogenic tumor and calcifying epithelialodontogenic tumor demonstrated negative.Odontogenic tumors which contained BMPwere just those odontogenetic tumors in which formation of enamel,dentin,or cem-ent was observed.So,BMP might be relate to formation of these tissues in odonto-genic tumors.