纤维凝集素在涎腺上皮性肿瘤中定位的免疫组织化学研究

An Immunohistochemical Studies on the Location of Fibronectin in Epithelial Tumors of Salivary Gland

用纤维凝集素抗血清,对32例涎腺肿瘤进行免疫组织化学(ABC 法)研究,旨在探讨这些肿瘤的结构性质及其组织发生。结果如下:1.多形性腺瘤中,部分肿瘤细胞结构周围有基底膜样 FN 环绕。部分肿瘤细胞结构周围有 FN 阳性细胞,且增殖,并和肌上皮片块、粘液软骨样区相延续。2.腺样囊性癌中,FN 在筛孔状结构呈围腔状分布,筛孔周围细胞为肿瘤性肌上皮细胞。3.腺淋巴瘤、基底细胞睬瘤、粘液表皮样癌、腺泡细胞癌中的肿瘤上皮结构周围基底膜区,FN呈线状环绕,表明这些肿瘤中不含肌上皮细胞,肿瘤细胞仅发生了腺上皮或鳞状上皮分化。4.各涎腺肿瘤中,肿瘤性上皮结构周围基底膜区和间质中 FN 分布的多寡和方式不同。

32 cases of salivary gland tumors were investigated immunohistochemically with thefibronectin antiserum to elucidate the histological characteristic of the tumors of the sal-ivary gland and its cell origin.The results are as follows:1.Fibroncctin-positive basement membrane-like structure could be found around somepleomorphic adenoma.The fibronectin-positive cells were also observed around somecells of pleomorphic adenoma.They were proliferation and migrated into areas of muco-eartilaginoid tissues and myoepithelial flanke and differentiated towards the myoepithel-ium and the mesenchymal tissue.2.Fibronectin was distributed cavity-likely in the pseudocystic structure of adenoidcystic carcinoma.There were tumorous myoepithelial cells around the pseudocysticstructure.3.The linear fibronectin structure could be observed in the basal membrane of tumorepithelia of adenolymphoma as well as basal cell adenoma,mucoepidermoid carcinomaand acinic cell carcinoma,suggestting that these tumors did not contain myoepithelialcell and differentiated toward the epithelioglandular or squamous epithelium.4.The number and style of fibronectin distribution were different between basalmembrane areas around tumorous epithelium structure and mesenchyma among differentsalivary gland tumors.