NHL的AgNOR定量研究及其预后的意义

AgNOR in Non-Hodgkin's Lymphomas—Its Prognostic Importance and the Value in Histolgical classification

核仁组成区相关嗜银蛋白(AgNOR)染色方法,是近年来肿瘤病理研究中的新技术。对32例非何杰金淋巴瘤(NHL)石蜡包埋切片进行了Ag NOR定量研究,探讨与组织类型及预后的关系。不同恶性程度组别的组织学类型之间以及存活组与死亡组之间AgNOR均数差别均具有高度显著性意义。AgNOR可望成为NHL组织分型及估计预后的一项新指标。

Argyrophil method for nucleolar organizer regions (AgNOR) hasbeen a new technique in the study of tumor pathology in recent ye-ars. As a silver staining technique, AgNOR has been quantitativelystudied in paraffin sections of 32 non-Hodgkin's lymphomas. A sig-nificant difference was found between the numbers of AgNOR inthe nuclei of low-grade lymphomas, intermediategrade lymphomasand those of high-grade lymphomas. The difference was also foundbetween the living group and dead group. It is suggested that thismethod should find application to the classification of NHL andmay be a new index of prognostic importance.