临床胃粘膜活检及胃癌手术标本纤维连结蛋白的定位观察

Observation of Fibronectin in Samples of Clinical Gastric Mucosa Biopsy and Gastric Cancer Operation

采用免疫组化及免疫电镜技术对临床胃粘膜活检及胃癌手术标本进行了纤维连结蛋白(FN)的定位观察。结果,FN见于胃粘膜上皮细胞和部分癌细胞内以及各种基底膜、间质中。肠化及异型增生上皮细胞FN染色增强,胃癌细胞和其基膜FN减少缺失且与癌细胞分化程度相关,胃癌间质FN丰富,尤其以癌浸润前缘明显。本文着重讨论了胃癌FN改变与癌细胞生物学特性的关系。

With immunohistochemical and immunoelectron microscopic te-chnique, FN in normal gastric mucosa, infesfinal mefaplasia、dyspl-asia and gastric cancer was observed. FN was present not only inthe epithelial cells and parts of cancer cells but in the basementmembrane and stroma as well. In intestinal metaplasia and dysplasia,cell-FN showed stronger staining. In gastric cancer, cell-FN andbasement membrane-FN were decreased with the declining of thecancer cell differentiation. Cancer stroma-FN was rich in the frontinfiltrative region. The emphasis about the relationship between FNand biological characteristics of cancer cells was discussed.