一步法合成2-芳基咪唑并[2,1-a]异喹啉等杂环化合物

A Novel Method for the Synthesis of 2-Arylimida zo(2,1-a)isoquinolines

由异喹啉、喹啉或酞腈与α 卤代苯乙酮反应生成的盐在二氢铬酸四吡啶合钴 (TPCD)存在下与乙酸铵反应 ,可一步法合成咪唑并 [2 ,1 a]异喹啉 (2a～ 2b)、咪唑并 [1,2 a]喹啉 (4a～ 4b)或咪唑并 [1,2 a]酞腈 (6a～ 6c)衍生物 ,该方法原料易得 ,反应条件易于控制 。

A one-pot procedure has been developed to prepare the derivatives of 2-arylimidazo(2, 1-a)-isoquinolines (2a similar to 2b), 2-arylimidazo(1, 2-a) quinolines (4a similar to 4b) and 2-arylimidazo(1, 2-a) phthalazines (6a similar to 6c) in moderate yields (51% similar to 62%) by the reaction of isoquinolinium salts, quinolinium salts or phdialazinium salts with ammonium acetate in the presence of tetrakispyridine cobalt(II) dichromate (TPCD).