人肝癌及癌周组织中HBsAg、HBcAg和糖原的研究

STUDY OF HBsAg, HBcAg AND GLYCOGEN IN HUMAN HEPATOCELLULAR CARCINOMA

用组化和免疫组化方法,对人肝癌癌旁组织中增生灶、增生结节与肝癌的关系及其HBsAg,HBcAg和糖原的表达进行了观察。结果表明,嗜酸性细胞和(或)透明细胞增生灶、增生结节与周围癌组织有明显过渡性;嗜酸性细胞增生灶、增生结节的HBsAg,HBcAg和糖原均可阳性表达。提示HBV在肝癌发生中起重要作用。作者对人肝癌发生的可能途径进行了讨论。

The relationship between hyperplastic foci and nodules and hepatocellular carcinoma (HCC), and the expression of hepatitis B surface antigen (HBsAg),hepatitis B core antigen (HBcAg) and glycogen in human HCC, were observed by histochemical and immunohistochemical methods. The results showed that there was an obvious transition from acidophilic cell and/or clear cell hype-rplastic foci and nodules to HCC, and that both acidophilic cell hyperplastic foci and nodules were positive for HBsAg, HBcAg and glycogen. The results suggest that hepatitis B virus (HBV) plays an important role in hepatocarcino-genesis. A hypothesis of hepatocarcinogenesis is proposed.