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The Expression of the Apoptosis-Suppressive Gene bcl-2 in the Tissue of Colon Carcinoma 被引量:1

The Expression of the Apoptosis-Suppressive Gene bcl-2 in the Tissue of Colon Carcinoma
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摘要 The role of bcl 2 in the pathogenesis of colorectal tumor were studied. The exp ression of bcl 2 in the colorectal carcinoma and incisional edge tissue of tumo r was detected by using SABC method. The results showed that the positive rate o f bcl 2 was 69.6 % in colorectal carcinoma and 47.6 % in the incisional edge ti ssue respectively, with the difference being very significant ( P =0.001). B cl 2 positive rate was associated with Dukes' stage, but had nothing to do with histological classification. It was concluded that bcl 2 might play a signific ant role in the development of colorectal carcinoma. The role of bcl 2 in the pathogenesis of colorectal tumor were studied. The exp ression of bcl 2 in the colorectal carcinoma and incisional edge tissue of tumo r was detected by using SABC method. The results showed that the positive rate o f bcl 2 was 69.6 % in colorectal carcinoma and 47.6 % in the incisional edge ti ssue respectively, with the difference being very significant ( P =0.001). B cl 2 positive rate was associated with Dukes' stage, but had nothing to do with histological classification. It was concluded that bcl 2 might play a signific ant role in the development of colorectal carcinoma.
作者 黄文广 姚璇
出处 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2002年第3期218-220,共3页 华中科技大学学报(医学英德文版)
基金 a grantfromNational Natural Science Foundationof China(No.3 9970 693 )
关键词 colorectal carcinoma bcl 2 oncoprotein apop tosis IMMUNOHISTOCHEMISTRY colorectal carcinoma bcl 2 oncoprotein apop tosis immunohistochemistry
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  • 1邱文才(译),国外医学肿瘤学分册,1994年,12卷,4期,195页
  • 2Sinicrope F A,Cancer Res,1995年,55卷,2期,237页
  • 3Kenji Sugamura,Masato Makino,Nobuaki Kaibara. Apoptosis as a Prognostic Factor in Colorectal Carcinoma[J] 1998,Surgery Today(2):145~150

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