HLA-DQB1基因与汉族天疱疮的相关性研究

The association between HLA-DQB1genes and pemphigus in Han Chinese in Jiangsu and Anhui Provinces

目的 : 探讨HLA -DQB1基因在天疱疮易感性中的作用。方法 : 用序列特异性引物 -聚合酶链反应 (PCR -SSP)方法 ,对 5 9例寻常型 (PV)患者、37例红斑型天疱疮 (PE)患者及 5 3例正常对照者进行了HLA -DQB1等位基因的分型 ,并分析了DQB1基因在两组中的分布。结果与结论 : 与正常对照组比较 ,PV与PE患者组中HLA -DQB1 0 30 2、DQB1 0 5 0 3基因频率明显增高。本研究结果提示 ,HLA -DQB1 0 30 2、DQB1 0 5 0

Objective:To investigate the predisposing role of HLA-DQB1 genes in pemphigus vulgaris.Method:Polymerase chain reaction-specific sequence primers to type HLA-DQB1 sub-region were used in 59 patients with pemphigus vulagris (PV) and 37 patients with pemphigus erythematosus (PE) of Han nationality from Jiangsu and Anhui Provinces and 53 matched control subjects.Results and Conclusions: The results demonstrated that HLA-DQB1*0302, HLA-DQB1*0503 gene frequencies were significantly higher in PV and PE patients than those in controls. It is suggested that HLA-DQB1*0302 and HLA-DQB1*0503 are the susceptibility markers for PV and PE in Han Chinese.