吸烟习惯与银屑病

Smoking habits in psoriasis

目的 : 探讨吸烟习惯与银屑病的关系。方法 : 采用问卷调查形式对有吸烟习惯的 72 5例银屑病患者及 72 5例对照进行调查 ,用EPIinfo软件对资料进行分析 ,对每个变量 ,计算银屑病的比值比 (OR)作为估计其相对危险性和 95 %的可信区间 (CI) ;χ2 值和P值。结果 : (1)病例—对照的社会阶层分析无统计学意义 (χ2 =0 .5 8,P =0 .4 5 )。 (2 )银屑病与目前的吸烟状况 (OR =2 .2 ,95 % ,CI 1.7～2 .7,P <0 .0 0 0 1)及发病前的吸烟状况 (OR =5 .6 ,95 % ,CI 4 .2～ 7.4 ,P <0 .0 0 0 0 1)具有明显的相关性。(3)吸烟与银屑病呈现明显的剂量反应关系 ,尤其是目前每天吸烟超过 2 0支以上的患者这种关系更为明显 (OR =2 .9,95 % ,CI 1.9～ 4 .3)。结论 : 吸烟习惯可能对银屑病的发生、发展起着重要的作用。

Objective: To determine the association between the smoking habit and psoriasis.Method: Patients with psoriasis and controls were interviewed with a structured questionnaire and the data were analyzed by Epi-info program. For each variable, the odds ratios (OR) and 95% confidence intervals were calculated.Results:(1) The distribution of social classes between patients with psoriasis and controls showed no significant difference (χ 2=0.58, P=0.45); (2) There was a significant association between psoriasis and current smoking status (OR=2.2, 95% CI, 1.7～2.7, P<0.0001). The association also existed between the development of psoriasis and previous habit of smoking (OR=5.6, 95%, CI 4.2～7.4, P<0.00001). (3) A dose-response relationship was obviously seen between the number of cigarettes smoked per day and the risk of development of psoriasis (χ 2=41.47, P< 0.0001 ). The association was stronger in those who currently smoked more than 20 cigarettes per day (OR= 2.9 , 95%, CI 19～4.3). Conclusion :The results suggest that smoking may play an important role in the development of psoriasis.