安乃近不良反应及急性中毒事件的文献分析

Literature Analysis of ADRs and Acute Poisoning Events Induced from Analgin

目的 :综述安乃近引起的各种不良反应的文献报道 ,为安乃近的临床再评价提供科学依据。方法 :通过查阅中国期刊网 (医药部分 )及Medline有关安乃近不良反应文献题录 ,检索 1986～ 2 0 0 1年国内外医药学术期刊有关文献并进行分析统计。结果 :服用安乃近致不良反应的 92名患者共发生不良反应 98例次。其中泌尿系统损害 5 6例次 ,占 5 7.1% ;血液及造血系统损害 17例次 ,占 17.3% ;过敏反应 11例次 ,占 11.2 % ;皮肤损害 9例次 ,占 9.2 % ;消化系统损害 5例次 ,占 5 .1%。92名患者中因过敏性休克、暴发性紫癜等严重反应致死 15例 ,占 16 .3%。此外 ,有 3名患者因超大剂量服用安乃近而造成毒性反应。结论 :安乃近所致药物不良反应以泌尿系统损害最为多见。因为过敏性休克等严重反应导致死亡的发生频度高 。

Objective: To review the literature report of varieties of ADRs induced by analgin to provide a scientific foundation for clinical revaluation of analgin. Method: The literature title related to analgin were consulted from the Chinese Journal Net (part of medicine) and Medline, the related literature in the internal and external medicine science journals in 1988-2001 were explored, and then both analysis and statistics were conducted. Result: Ninety-two patients with ADRs induced from analgin by oral administration occured 98 cases/occasions ADRs, of which, 56 cases/occasions of urinary system harms(57.1%), 17 of blood and hematopoietic system harms(17.3%), 11 of anaphylactic reactions(11.2%), 9 of dermal harms(9.2%), 5 of digestive system harms(5.1%), Of 92 patients, 15 cases died because of severe reactions such as anaphylactic shock and purpura fulminans(16.3%). Moreover, 3 cases occured the toxicity reactions induced form overdose of analgin. Conclusion: The urinary system harms are most common in analgin-induced ADRs. The occuring frequency of dead induced form severe reactions such as anaphylactic shock, the special care must be taken by clinical physicians.