新型外周镇痛药物作用靶点——辣椒素受体

Capsaicin receptor,a novel target for new peripheral acting analgesics

辣椒素受体是表达于感受痛觉的中枢感觉神经元伤害性感受器上的阳离子通道 ,与人体对伤害性冲动的感受和痛觉的产生密切相关。实验条件下 ,辣椒素受体激动 ,机体会产生痛觉反应。而敲除辣椒素受体的动物则对某些伤害性刺激 ,如辣椒素、H+ 、热 (>43℃ )极不敏感。随着研究的深入 。

The capsaicin (vanilloid) receptor is a cation channel expressed by primary sensory neurons of the 'pain' pathway, which accounts for the pain sensation of nociceptive stimulation.In laboratory research,the mice showed pain behavior after the activation of capsaicin receptor.The capsaicin receptor null mice were severely deficient in their responses to the noxious stimuli of capsaicin,acid,or heat(>43℃). With the research furthering,more attention has been paid to the capsaicin receptor 1(VR1) as a novel target for analgesics.\;