摘要
对新型抗寄生虫药塞克硝唑的作用机制、药效学、药代动力学、毒理及临床应用情况作一简要综述 ,并与其他 5 硝基咪唑类药物的特性作比较。塞克硝唑与其他硝基咪唑类药物一样具有抗原生虫的生物活性 ,口服吸收良好 ,生物利用度为 (1 0 0± 2 6) % ,单剂量口服塞克硝唑 0 .5～ 2 g ,Cmax为 35 .7～ 46 .3mg·L- 1 ,Tmax为 1 .42～3h ,消除半衰期 (t1 /2 β)为 1 7～ 2 9h。毒性试验表明 ,塞克硝唑毒性极低且具有良好的耐受性 ,半数致死量 (LD50 )约2 .5g·kg- 1 。塞克硝唑临床上主要用于阿米巴虫病、贾第虫病、滴虫病和细菌性阴道炎的治疗。
Secnidazole is a new drug of nitroimidazole family.Its pharmacology properties are similar with other nitroimidazoles,such as metronidazole and tinidazole.In this paper,the mechanism of action,pharmacology,pharmacokinetics properties,toxicity and clinical application of secnidazole were reviewed. Just like other nitromidazole drugs,secnidazole has the antimicrobial activity.It can be absorbed orally,and its biological availability is (100±26)%.With secnidazole at a single 0.5～2g dose orally, C max is 35.7～46.3mg·L -1 ,the T max is 1.42～3h, t 1/2 β is 17～29h. The safety and tolerability of secnidazole is good.The LD 50 of secnidazole is 2.5g·kg -1 .In clinical research,secnidazole single dose treatments are widely used in the treatment of amoebiasis,giardiasis,trichomoniasis and genitourinary infections.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2002年第10期765-766,共2页
Chinese Journal of New Drugs
关键词
塞克硝唑
药理
临床
secnidazole
pharmacology
clinical application
