不同给药方式和不同剂量奥美拉唑对消化性溃疡出血患者胃内pH的影响

Effect of different dosage and administration of omeprazole on intragastric pH in patients with bleeding peptic ulcer

目的 :对比不同给药方式和不同剂量奥美拉唑对消化性溃疡合并消化道出血患者胃内 pH的影响。方法 :2 8例消化性溃疡合并上消化道出血患者分别给予奥美拉唑 40mg ,qd(n =7) ,80mg ,qd(n =1 3)和 40mg,q1 2h(n =8) ,静脉输注。持续监测患者 2 4h胃内pH值 ,观察起效时间、pH持续时间、2 4h胃内平均pH和最高 pH。 结果 :奥美拉唑 80mg·d- 1 使胃内 pH >6的时间和平均 pH显著提高。奥美拉唑 80mg·d- 1 ,分 2次间歇输注维持消化性溃疡患者胃内 pH >4和pH >6的时间最长 ,且 pH >4的时间较 80mg·d- 1 持续静脉输注者显著延长。结论 :奥美拉唑 80mg·d- 1 ,分 2次间歇输注对于维持消化性溃疡患者胃内高 pH更为有效 ,并更有利于止血。

Objective:To investigate the effect of different dosage and administration of omeprazole on intragastric pH in patients with bleeding peptic ulcer.Methods:28 patients were divided randomly to receive omeprazole 40mg,qd( n =7);omeprazole 80mg,qd( n =13);or omeprazole 40mg,q12h( n =8).Intragastric pH was measured by a pH recorder for a duration of 24 hours.Results:The duration of intragastric pH>6 in patients treated with omeprazole 80mg,qd or 40mg,q12h was significantly longer,and mean intragastric pH was also significantly higher than that in the patients treated with omeprazole 40mg,qd.The duration of intragastric pH>4 and pH>6 in patients treated with omeprazole 40 mg,q12h was longer,and mean intragastric pH was also significantly higher than that in the patients treated with omeprazole 80 mg,qd.Conclusion:Omeprazole 40 mg intravenous infusion every 12 hours could maintain high intragastric pH,and may have advantages to hemostasis.