采用SAS软件包进行半数致死量(LD_(50))的计算

Calculation of LD_(50) using SAS

目的 :采用国际上通用的 SAS统计软件包编写的程序计算 L D50 、95 %可信限和平均可信限率 (FL % )等。 方法 :以吡嘧司特钾的急性毒性实验为例 ,采用 SAS统计软件包编写程序 ,以 Bliss法计算 L D50 、95 %可信限和 FL %等。结果 :吡嘧司特钾的 LD50 =(12 48.2 3± 14 1.2 10 ) mg/kg,FL% =11.3 1%。 结论 :采用 SAS统计软件包进行 LD50 等计算简便、快速。

Objective: To calculate the LD 50 , 95% fiducial li mi ts(95%FL) and percentage fiducial limits of error(FL%) using SAS, an internation al standard statistical tool. Methods: The LD 50 , 95%FL an d FL% of pemirolast potassium,as an example, were calculated using the program o f SAS. Results: The calculated results of pemirolast potassium were as follows: LD 50 =(1 248.23±141.210) mg/kg, FL%=11.31%.Concl usion: The SAS can be used for calculating LD 50 easily, quickly a nd accurately. [