孕期铁缺乏症妇女免疫细胞活性观察

Observation on Immunologically Cell Competence of Pregnant Women with Iron Deficiency

目的 分析孕期铁缺乏和缺铁性贫血 (IDA)时妇女免疫细胞功能的变化。方法 检测 12 8名铁缺乏和 5 2名正常孕妇及 5 0名孕前妇女的T淋巴细胞亚群CD+ 3 、CD+ 4 、CD+ 8和自然杀伤 (NK)细胞CD16活性 ,分析孕妇不同程度铁缺乏时各免疫指标的变化。结果 孕期妇女外周血T细胞亚群CD+ 3 、CD+ 4 细胞百分比及CD+ 4 /CD+ 8比值显著低于非孕育龄妇女 ;孕期妇女随着铁缺乏程度的加重 ,CD+ 3 、CD+ 4 细胞的百分比随之下降 ;IDA孕妇的CD+ 3 、CD+ 4 细胞的百分比、CD+ 4 /CD+ 8比值显著低于正常孕妇 (P <0 0 1,P <0 0 5 ,P <0 0 5 ) ;IDA孕妇CD16细胞百分比低于正常孕妇 ,但尚无显著性差异。结论 铁缺乏孕妇T细胞亚群数量改变 。

Objective In order to review the changes in cellular immune function in pregnant women with iron deficiency.Methods T lymphocyte subsets level(CD + 3?CD + 4 and CD + 8) and nature kill cells activity (CD 16 ) were determined in 128 iron deficiency pregant women,52 normal prenant women and 50 women before pregnancy were examined.Results The level of T lymphocyte subsets,percentages of CD + 3 and CD + 4 cells as well as the ratio of CD + 4/CD + 8 cells in the pregnant women were signficantly lower than that of those non-pregnant women.During pregnancy,with the increase of iron deficiency,the percentages of CD + 3 and CD + 4 cells in bodies of pregnant women decreased.The pregnant women of iron deficiency anemia(IDA) reduced percentages of CD + 3 and CD + 4 cells as well as the ratio of CD + 4/CD + 8 compared with normal pregnant women( P<0 01,P<0 05,P<0 05 );The percentage of CD 16 in pregnant women of IDA was lower than that of normal pregnant women,but no significant change.Conclusion There was significant effects of iron deficiency on T lymphocyte subsets level during pregnancy.The relationship between iron deficiency and nature kill cells activity needed to be studied further.