茶多酚对辐照后小鼠生存状况与血中白细胞数影响的研究

Effects of tea polyphenols on mice survival rate and white blood cell count after radiation

为评价茶多酚对小鼠的抗辐射作用 ,将 60只小鼠作为抗辐射I组 ,动态观察白细胞数。另 60只小鼠为抗辐射Ⅱ组 ,进行存活试验。结果表明 ,小鼠经口给予不同剂量茶多酚 ,辐照后各次试验中小鼠血中白细胞数均与对照组无显著性差异 ,茶多酚在大剂量照射时对小鼠白细胞保护作用不明显。 0 83和 2 5 0mg kgBW组小鼠存活率和对照组间比较 ,均有极显著性差异 (P <0 0 1 ) ,对照组辐射后 30天无一存活。

In order to evaluate the anti\|radiation effect of TPP (tea polyphenols), 60 female Kunming mice were chosen as group I for WBC (white blood cell) count, and another 60 female Kunming mice were set as group II for survival test. TPP was administrated orally to the mice. The results revealed that no significant difference was observed in the number of white blood cells in every test after the irradiation compared with that of the control group. Consequently, TPP showed no observably effect on the protection of the number of WBC against high dose irradiation. However, Mice survival rate of 0 83ml/kg BW group and 25 0ml/kg BW group are remarkably higher than that of the control group( P <0 01). On the contrary, the control group had no survivor 30 days after the irradiation. This suggested that TPP can increase the survival rate evidently on mice after irradiation.