软肝合剂联合干扰素治疗乙肝后肝纤维化25例临床研究

Clinical study on treatment of 25 cases of hepatic fibrosis after hepatitis B With Ruan Can Mixure combined with interferon

目的:观察软肝合剂联合干扰素对乙型肝炎及肝纤维化的治疗作用。方法:所有观察对象随机分为治疗组(用软肝合剂联合干扰素治疗)和对照组(用干扰素治疗),观察两组间治疗前后HBV—DNA、HBeAg、肝功能、血清透明质酸(HA)、Ⅳ型胶原(Ⅳ-C)、层粘蛋白(LN)水平变化情况。结果:两药联用较对照组在HBV—DNA及HBeAg转阴率方面差异无显著性(P>0.05),治疗组天冬氨酸转氨酶(AST)、丙氨酸氨基转氨酶(ALT)下降较对照组差异有非常显著性(P<0.01),治疗组血清HA、IV—C、LN水平下降程度较对照组差异有非常显著性(P<0.01)。结论:软肝合剂联用干扰素在抗病毒方面无协同增效作用,而在保肝、抗纤维化方面有协同增效作用。

Purpose: To observe on therapeutic action of Ruan Gan Mixture combined with interferon on hepatitis B and hepatic fibrosis. Methods: The cases were randomly divided into the treatment group treated with Ruan Gan Mixture combined with interferon, and the control group treated with interferon, and HBV-DNA. HBeAg. hepatic function, serum HA. IV - C and LN levels before and after treatment were observed. Results. Aspartate aminotransfera.se (AST). Alanine aminotransferase (ALT), and serum HA. IV - C and LN levels in the treatment group decreased significantly (P < 0. 01), but HBV - DNA. and HBeAg negative - turning rate did not significantly change in the treatment group as compared with the control group (P>0. 05). Conclusion: Ruan Gan Mixture combined interferon have cooperative effect - increasing action in protective liver and anti - fibrosis.