支原体感染及产褥感染与新生儿窒息关系的研究

Relevance of mycoplasma infection, puerperal infection and asphyxia neonatorum

目的 研究围生期孕妇支原体感染与产褥感染及新生儿窒息的关系。方法 采用支原体培养法检测围生期孕妇阴道解脲支原体 (Uu)和人型支原体 (Mh) ,根据检测的结果将 2 480例孕妇分为支原体阳性组和支原体阴性组 ,观察两组产褥感染及新生儿窒息发生率。结果 支原体阳性组 110 0例 ,产褥感染发生率为4.4% (4 8/ 110 0 ) ,阴性组 1380例 ,产褥感染发生率为 3.2 % (4 4/ 1380 ) ,两组间差异无显著性 (P >0 .0 5 ) ;进一步分组研究发现Mh(+)Uu(+)亚组产褥感染发生率显著高于支原体阴性组 (RR3.78,95 %CI 2 .13～ 6 .6 9,P<0 .0 5 ) ,各亚组间新生儿窒息发生率差异无显著性 (P >0 .0 5 )。

Objective To explore the relevance of genital mycoplasma infection, puerperal infection and neonatal asphyxia during perinatal period. Methods Vaginal ureaplasma urealyticum(Uu) and mycoplasma hominis(Mh) were detected by the method of mycoplasma culture in 2 480 pregnant women who were randomly enrolled into the study, They were divided into positive group (n=1 100) and negative group(n=1 380) based on the cultural results.Results The studies showed that the incidence of puerperal infection in the positive group was 4.4%(48/1 100) and 3.2%(44/1 380) in the negative group, there was no statiscal difference in the incidence of puerperal infection and asphyxia neonatorum between the two groups. Further study showed that the incidence of puerperal infection in the subgroup with Uu(+)Mh(+) was significantly higher than that in the subgroup with Uu(-)Mh(-) (11.7% vs 3.2%, RR 3.78, 95%CI 2.13-6.69,P<0.05).Conclusion Mixed genital mycoplasma infection during perinatal period may lead to puerperal infection and asphyxia neonatorum.