六味地黄汤中马钱子素小鼠体内药代动力学研究

Pharmacokinetic study of loganin in LIUWEI DIHUANG DECOCTION in mice

目的 研究六味地黄汤中马钱子素小鼠体内药代动力学。方法 高效液相色谱 -紫外检测法。结果 六味地黄汤小鼠 ig给药后 ,马钱子素的药代动力学模型为单室模型一级吸收 ,其药代动力学参数为 K a=0 .0 4m in- 1 ,K e=0 .0 19m in- 1 ,T(peak) =42 .4min,t1 / 2 ka=17.4m in,t1 / 2 ke=35 .75 m in。结论 此药代动力学参数可能是六味地黄汤中马钱子素受其他成分影响所致。

Object To study the pharmacokinetics of loganin in LIUWEI DIHUANG DECOCTION (LWDHD) in mice. Methods HPLC-UV detection was used to determine the loganin levels in biological samples. Results After ig LWDHD in mice, the plasma concentration-time course fitted well to one-compartment model with the 1st order absorption and with the following pharmacokinetic parameters; Ka= 0.04min -1, Ke=0.019 min -1, T (peak)=42.4 min, t 1/2ka=17.4 min, t 1/2ke=35.75 min. Conclusion The pharmacokinetic parameters of loganin obtained in the study may be attributed to the effect of other constituentsin the DECOCTION.