四川省自贡市幼儿园3至5岁儿童乙型肝炎病毒感染情况及影响因素

PREVALENCE AND INCIDENCE OF HEPATITIS B VIRUS INFECTION IN 3-5 YEARS OLD KINTERGARDEN CHILDREN

为了解四川省自贡地区3～5岁幼儿乙型肝炎病毒(HBV)感染情况,并探索与感染有关的因素,1985年调查了1167名幼儿,其HBV总感染率为41.13％,HBsAg阳性率12.68％。幼儿的HBV感染与母亲HBsAg阳性密切相关。共检查母亲409例,38例HBsAg阳性,其幼儿HBsAg阳性率为50％(19/38),HBsAg阴性的母亲371例,其幼儿HBsAg阳性率9.97％(37/371),来自HBsAg阳性母亲的阳性子女占33.3％(19/56)。1986年随访HBV易感幼儿448例,HBV年感染率为12.95％(58/448),HBsAg年阳转率3.79％。HBV年感染率与原幼儿班级HBsAg阳性率的高低有关。

To determine the HBV infection in children aged 3-5 years in kinter-gardens, we examined 1,167 children in 7 seven day kindergartens of Zi-gong city, Sichuan Province, by HBV RIA kits from 1985-1986. The HBV prevalence rate was 41.13% and HBsAg positivity rate was 12.68%. Fifty per cent of the children of HBsAg positive mothers have HBsAg-antigenemia, compared to 9.97% in HBsAg negative mothers. The HBV infection rate per year in 448 HBV susceptibles was 12.95%, 3.79% of whom were HBsAg positive. The newly infected children were directly correlated to the numbers of HBsAg carriers present in the classes, P< 0.05.