HBsAg阴性母亲的新生儿接种不同剂量乙型肝炎血源疫苗的效果

EFFECTIVENESS OF PLASMA-DERIVED HEPATITIS B VACCINE IN NEWBORNS OF HBsAg NEGATIVE MOTHERS

HBsAg阴位母亲的新生儿,按0,1、6月程序分别接种10-10-10μg(1组)、20-10-10μg(2组)和30-10-10μg(3组)乙型肝炎血源疫苗。第一针后一年,检查抗-HBs阳转率,分别为87.60％,90.64％和88.97％,无统计学显著差异。3针10μg组免疫后l～4年抗-HBs阳性率分别为88.31％、81.08％、80.10％和78.39％,虽稍下降,但无统计学显著差异。3个剂量组HBsAg阳性率分别为0.71％,0.49％和0.74％,说明HBsAg阴性母亲的新生儿,用国产血源HBsAg疫苗免疫以10μ×3效果较理想。

The effectiveness of various, doses of plasma-derived HB vaccine on newborns of HBsAg negative mother immunized by 0,1,6 schedule is reported. The anti-HBs seroconvertion rates were 87.69%,90.64% and 88.79% for 10-10-10ng, 20-10-10μg and 30-10-10μg dosages respectively one year after the first in jection ( 10μg × 3 ) .The HBsAg rate were 0.71%, 0.49% and 0.74% respectively. There is no statistically significant difference between the three dosages. The Sero-positives rates were 83.31%, 82.15%, 74.89%, and 78.39% in the 10μg×3 group after 1,2,3 and 4 years of the immunization respectively. The results indicate that the 10μg/ml of vaccine is good enough to protect infants born to HBsAg negative mothers.