肝纤维化与门脉高压关系的实验研究

An Experimental Study of the Relationship between Hepatic Fibrosis and Portal Hypertension

本研究旨在阐明肝纤维化与门脉高压的关系,以及后向血流学说与前向血流学说间的内在联系。结果表明:肝纤维化程度与门脉高压增高幅度及侧枝循环开放有密切关系。肝纤维束宽度为469.3±137.5μm时,门脉压为1.91±0.23kPa,无侧枝循环开放及(或)腹水形成;肝纤维束宽度为806.02±125.6μm时,门脉压为2.54±0.37kPa,出现侧枝循环开放及(或)腹水形成。肝纤维束宽度与门脉高压的相关系数(γ)为0.685(P<0.05),提示后向血流学说是门脉高压症的发病基础。

The purpose of the present article is to investigate the relationship between heaptic fibrosis and portal hypertension. The model of hepatic fibrosis and/or cirrhotic portal hypertension in 12 dogs by common bile duct ligation was performed. Among these 12 dogs, 6 had well-developed portal hypertension, diffuse cirrhotic nodules and pseudolobules with broad bundles of fibrotic tissue (806.02±125.6 μm), 5 of which resulted in formation of collateral circulation and ascites, and the remaining 6 only suffered from moderate portal hypertension with narrow bundles of fibrotic tissue (469.3±137.5 μm) but without formation of collateral circulation and ascites. The results showed that the broader the bundle of fibrotic tissue was, the more elevated the portal hypertension was. To be more exact, the increased resistance to portal blood flow due to hepatic fibrosis (backward flow theory) is more important than the increased splanchnic blood flow(foreward flow theory) in the genesis of portal hypertension.