慢性阻塞性肺病患者肺动脉压与血液流变学的关系

Correlation of Pulmonary Arterial Pressure with Hemorheology in COPD Patients

本研究对比观察了50例缓解期慢性阻塞性肺病(COPD)患者肺动脉压与其全血比粘度、血浆比粘度、红细胞比积的关系。结果表明:显性肺动脉高压组患者的全血高、低切变率的比粘度、红细胞比积均高于正常肺动脉压和隐性肺动脉高压组的患者(P均<0.01);全血高、低切变率的比粘度和红细胞比积均与静息时肺动脉平均压呈显著正相关(γ分别为0.51、0.64、0.72,P均<0.01)。提示COPD患者肺动脉高压的发生与血液粘滞度的增高有一定关系。

This study was conducted to investigate the correlation between the pulmonary arterial pressure and hemorheology in 50 stable COPD patients by Swan Ganz catheterition and hemorheologie technique. The results show that the blood viscosity both at high and low shear rate and hematocrit in COPD patients with dominant pulmonary hypertension were much higher than those in COPD patients without pulmonary hypertension and with latent pulmonary hypertension, and the blood viscosity at high or low shear rate and hematocrit, all have significant correlation with the resting pulmonary arterial mean pressure (r=0.51; 0.64; 0.72; P<0.01). From the above it may be suggested that the development of pulmonary hypertension in COPD patients has something to do with the increased blood viscosity.