放置不同宫内节育器妇女子宫内膜纤溶酶原激活物活性测定

Activity of Plasminogen Activators in the Endometrium of Women Using Copper IUD or Levonorgestrel-releasing IUD

本文采用S-2251底物显色法,对放置T形含铜宫内节育器(TCu-IUD)致月经过多,T形含18-甲-炔诺酮宫内节育器(18-甲-IUD)月经过少或闭经、未放置宫内节育器(IZD)月经正常者的子宫内膜纤溶酶原激活物(t-PA)活性进行测定。结果表明:TCu-IUD组子宫内膜t-PA活性为111.3±44.6 IU/mg蛋白((?)±s),明显高于对照组(44.2±16.2 IU/mg蛋白)和18-甲-IUD)组(39.4±14.9 IU/mg蛋白),差异有极显著性意义,(P均<0.01),后两组间差异无显著性意义(P>0.05)。研究表明:子宫内膜之t-PA活性增加是放置IUD妇女月经过多的重要原因。

The activity of tissue plasminogen activator (t-PA) was measured by chromgenic substrate S-2 251 method in endometrium of women with TCu-IUD induced menorrhagia (MBL 80), and of levonorgestrel-IUD users with oligomenor-rhea or amenorrhea. Non-IUD users with normal menses (MBL 80) were chosen as normal controls. The result showed that the t-PA activity of TCu-IUD group was significantly higher than that of levonorgestrel-IUD group and the control group (P<0.01), and there was no statistical difference between levonorgestrel-IUD group and the control group (P>0.05). Our experimental results indicate that the enhancement of t-PA activity may be an important factor contributing to IUD-induced menorrhagia.