平阳霉素治疗翼状胬肉的临床及病理观察

Clinical and Pathological Observations on Treatment of Pterygium with Pingyangmycinum

对116例(132)眼各种翼状胬肉局部用平阳霉素注射治疗。结果有效率为:进行性97.5％;静止性94.3％;A级93.5％;B级66.7％;C级56.1％;总有效率96.2％。疗效与胬肉是否活动无关,与大小有关。注射后胬肉萎缩者,病理组织学可见胬肉间质呈纤维样变性,部分呈玻璃样变性,严重者坏死。胬肉间质血管明显减少或消失,纤维细胞减少。对平阳霉素治疗的机理与毒副作用进行了讨论。

This study presents a report of the results of treatment by topical injection of pingyangmycinum to 116 cases (132 eyes) of pterygium. The effectiveness rate of progressive type is 97.5%; that of quiescent type 94.3%; Grade A 93.5%; Grade B 66.7%; and Grade C 56.1%; with a total effectiveness rate of 96.2%. The effect of treatment is related to the size of pterygium, not to its activity. Pathohistologically, fibroid degeneration in interstitial tissues of pterygium can be seen in pterygium atrophy cases after injection, hyaline degeneration in patial cases and necrosis in serious ones. Blood vessels in interstitial tissues decrease markedly or disappear, and so do fibrocytes. The mechanism and toxic effects of treatment with pingyangmycinum are also discussed.