药敏指导下的晚期乳腺癌化疗

Chemotherapy of Advanced Breast Cancer under Guidance of Chemosensitivity Test (SRC Assay)

1982年,我们开始用正常小鼠肾包膜下移植方法(SRC)测定抗癌药物的敏感性。1986年应用临床治疗女性晚期乳腺癌。本文报告22例,年龄37～60岁,,除2例外,先前曾接受过放疗、化疗。22例中,单药治疗14例,联合用药8例。按国际通用标准评定疗效。结果,单药组及联合用药组的有效率分别为64％和87.5％,明显优于常用有效单药及联合化疗方案。

From Oct. 1986 to Dec. 1987, 24 patients with advanced breast cancer were treated by chemotherapy under the guidance of tumor response to chemotherapeutic agents with a 6-day subrenal capsule (SRC) assay. Among 22 evaluable cases, 14 cases were treated with single drug and 8 cases with combined agents. According to WHO's criterion for evaluating therapeutic effects, response rate of 64% was achieved in single drug group and 87.5% in combined agents group, which were evidently superior to chemotherapy given empirically.