柯萨奇病毒B3诱导人心肌纤维细胞因子的产生

CYTOKINES OF HUMAN MYOCARDIAL FIBROKLASTS INDUCED BY COXSACKIE VIRUS B3

目的 探讨柯萨奇病毒与心肌炎的关系。方法 采用ELISA方法检测了感染CVB3心肌纤维细胞培养上清液IL - 6、IL - 8、IL - 1α、IL - 1β和TNF -α的产生。 结果 发现感染CVB32 4h后IL - 6和IL - 8明显升高 (P <0 .0 1) ,96h后IL - 1α有所升高 (P <0 .0 5 ) ,IL - 1β和TNF -α无明显变化。 结论 IL - 6、IL - 8和IL -

Objective Infection with CVB3 may cause severe cardiovascular disease. The mechanisms are not clear.Cytokines may have important functions,but which kind of cells they come from is not known.Myocardial Fibroklasts is the main cells.The cytokines were determined after infection with CVB3.Methods IL-6、IL-8、IL-1α、IL-1β and TNF-α in the supernate were measured with ELISA.Results IL-6 and IL-8 increased significantly after CVB3 infection(P<0.01).IL-1α increased too(P<0.05). No changes in IL-1β and TNF-α.Conclusion IL-6、IL-8 and IL-1α may have some function in the CVB3 myocarditis.