血清总唾液酸测定与活动性类风湿性关节炎的相关性分析

Determination of serum total sialic acid and correlative analysis in patients with active rheumatoid arthritis

目的 探讨血清总唾液酸（Total sialic acid;TSA）与活动性类风湿性关节炎的关系。方法用快速单一化学试剂法测定血清中TSA。结果56例活动性类风湿性关节炎患者的TSA水平为812±106mg/L;37例非活动性类风湿性关节炎组TSA水平为672±83mg/L,两组比较有显著性差异（P<0.01）。结论 TSA是推断活动性类风湿性关节炎的生化指标之一,和经典指标联合应用更能反应类风湿性关节性活动的存在。

Objective To study the clinical significance of total serum sialic acic (TSA) in patients with active rheumatoid arthritis (ARA), and to provide a new biochemistry marker for patients with ARA. Methods TSA of ARA patients was measured by single chem -reagent, and evaluated in comparison with classic markers and clinical course of patients with ARA. Resuls The average value of TSA of 56 patients with active rheumatoid arthritis and 37 with non-active rheumatoid arthritis were 812±106mg/ L and 672±27mg/L respectively. The mean value of TSA in ARA patients was significantly higher than that of non-active rheumatoid arthritsis patients (P<0.01). Conclusion TSA may be used as a new biochemical indicator for the activity of rheumatoid arthritis. The combination of TSA and classic markers is helpful in the analysis of activity of ARA.