胃起搏对胃动力紊乱犬胃电活动的影响

Effects of gastric pacing on the gas-tric myoelectrical activity of a canine model of gastric motor disorders

目的:探索胃起搏对胃动力紊乱犬胃电活动的影响.方法:采用双侧迷走神经干切断术联合应用胰高血糖素建立胃动力紊乱犬模型;采用4导联胃肠电系统微机分析仪记录胃肠浆膜肌电活动;采用适宜的起搏参数行有效的胃起搏,观察起搏治疗前后胃动力紊乱犬胃电参数的变化.结果:治疗前模型犬餐后的胃电频率(4.85±0.40次/min)、胃电幅度(2.32±0.35mV)及慢波的传播速度(4.06±0.40cm/s)较正常对照犬均显著降低(5.37±0.36次/min,4.25±0.12mV,6.92±0.24cm/s)(P<0.03);胃起搏治疗后,模型犬餐后的胃电频率(5.49±0.31次/min)、胃电幅度(3.97±0.19mV)和慢波的传播速度(5.57±0.48cm/s)匀明显高于治疗前(P<0.05);胰高血糖素诱发了模型犬和正常犬餐后的异常胃电节律,其中模型犬的规则慢波节律百分数从用药前的87.6±3.4%减少到10.0±6.7%(P<0.001),而正常对照犬从97.1±0.8%减少到35.0±11.0%(P<0.01),但采用适宜参数行胃起搏可100%诱发慢波.结论:采用适宜的起搏参数进行胃起搏可从腹部体表完全触发胃电慢波,改善胃电参数,纠正药物导致的异常胃电节律.

AIM:To investigate the effects of gastric pacing on gastricmyoelectrical activity of a canine model of gastric motordisorders.METHODS:A canine model of gastric motor disorders wasestablished by truncal vagotomy combined with injectionsof glucagon;Gastric serosal myoelectrical activity was re-corded using four-channel computer analysis instruments;The optimal pacing parameters were applied for the effec-tive gastric pacing, and the changes of gastric myoelectricalparameters of model dogs were observed before and aftergastric pacing.RESULTS:Basic electrical rhythm (BER) frequency (4.85±0.40cycles/min) , amplitude (2.32±0.35 mV) and propagationvelocity (4.06±0.40 cm/s) of model dogs in the fed state de-creased significantly than that of the control dogs (5.37±0.36cycles/min, 4.25±0.12 mV, 6.92±0.24 cm/s) (P < 0.03);After gastric pacing treatment, BER frequency (5.49±0.31cycles/min);amplitude (3.97±0.19 mV) and propagationvelocity (5.57±0.48 cm/s) increased significantly than thatof before pacing (P < 0.05);The glucagon injection pro- voked a dysrhythmias in all dogs, the percentage of theregular slow wave of model dogs was apparently reducedfrom 87.6±3.4 % at baseline to 10.0±6.7 % (P < 0.001),and that of intact dogs decreasing form 97.10±0.8 % to35.0±11 % (P < 0.01), but the inducement of gastric slowwave was 100% when gastric pacing at optimal parameters.CONCLUSION: Surface gastric pacing using the optimal pac-ing parameters is able to entrain completely the gastricslow wave, improve parameters of gastric myoelectrical ac-tivity and normalize gastric dysrhythmias induced by phar-macological agent.