单一中医治疗或联合方案治疗过敏性鼻炎的网状META分析

Network Meta Analysis of single Chinese medicine treatment or combined treatment for treatment of allergic rhinitis

目的:采用网状Meta分析评价单一中医治疗或联合方案治疗过敏性鼻炎的临床疗效。方法:检索中国知网数据库、中国生物医学文献数据库、维普全文期刊数据库、万方数据库,利用网状Meta分析方法,纳入单一中医治疗或联合方案治疗过敏性鼻炎的随机对照研究,由两名研究者按照Cochrane手册5.1.0标准对每项纳入的研究进行质量和偏倚风险评估,数据采用ADDIS 1.16.8软件及STATA软件进行网状META分析。结果共纳入43项研究(3936例患者)。结果:中医联合疗法治疗过敏性鼻炎有效率优于单一中医疗法,针刺结合中药,针刺结合穴位敷贴,中药结合穴位敷贴和中药结合推拿与单纯针刺/单纯中药/单纯穴位敷贴之间疗效差异具有统计学意义(P <0.05);中药结合耳穴贴压与单纯耳穴贴压之间疗效差异具有统计学意义(P <0.05),但排序结果显示不同的干预措施对不同的结果指标影响不一样。结论:中医联合方案治疗优于单一中医治疗,但确切的结论尚需要高质量的临床研究进行进一步验证.

Objective: Use network meta analysis to evaluation of clinical efficacy of single Chinese medicine treatment or combination treatment for allergic rhinitis. Methods: CNKI, CBM, VIP and the Wanfang database were searched. The randomized controlled trial of a single Chinese medicine treatment or a combination treatment for allergic rhinitis using a network meta-analysis, with two investigators assessing the quality and bias of each included study according to the Cochrane Handbook 5.1.0 criteria. The data was analyzed by ADDI 1.16.8 software and STATA software for network meta analysis. A total of 43 studies(3936 patients) were included.Results: TCM combination therapy is more effective than single Chinese medicine in the treatment of allergic rhinitis. The difference between acupuncture combined with traditional Chinese medicine, acupuncture combined with acupoint application, traditional Chinese medicine combined with acupoint application and traditional Chinese medicine combined with massage and acupuncture/Chinese medicine/acupoint application was statistically significant(P < 0.05). The difference between traditional Chinese medicine combined with auricular acupoint pressing and auricular acupoint pressing was statistically significant(P < 0.05), but the ranking results showed different interventions. The impact on different outcome indicators is different. Conclusion: The combination of traditional Chinese medicine treatment is better than single Chinese medicine treatment, but the exact conclusion still needs high quality clinical research for further verification.