谷胱甘肽硫转移酶T1基因多态性与喉癌易感性的Meta分析

Meta-analysis of glutathione S-transferase t1 gene polymorphism and laryngeal cancer risk

目的探讨谷胱甘肽硫转移酶T1(glutathione S-transferase T1,GSTT1)基因多态性与喉癌易感性的关系。方法全面检索ISI Web of Knowledge、Pubmed、Embase和中国期刊全文数据库,按照纳入排除标准纳入文献,进行Meta分析,并按照种族类别和对照来源进行亚组分析。结果纳入文献15篇,GSTT1空白基因型与喉癌易感性通过综合定量分析无统计学关联(Z=1.84,OR=1.44,95%CI:0.97-2.12)。亚组分析表明在高加索人群(Z=0.90,OR=1.12,95%CI:0.87-1.45)和亚洲人群(Z=1.96,OR=5.63,95%CI:1.00-31.83)中均无统计学关联;在医院为基础的病例对照研究(Z=1.48,OR=2.17,95%CI:0.78-6.02)和社区为基础的病例对照研究(Z=0.13,OR=1.03,95%CI:0.71-1.49)中均无统计学意义。结论 GSTT1空白基因型与喉癌发生风险无关联。

OBJECTIVE To evaluate the possible associations of GSTT1 gene polymorphism with laryngeal cancer risk. METHODS The relevant studies were identified through the search of PubMed, Embase, ISI Web of Knowledge and Chinese National Knowledge Infrastructure,and all the articles were selected on the basis of the established inclusion criteria for publications. Data were analyzed through meta-analysis, which were conducted according to the subgroups of studies based on ethnicity and source of controls. RESULTS Fifteen studies were included in the present meta-analysis. The combined results based on all studies showed that GSTT1 null genotype was not associated with laryngeal cancer risk(Z=1.84, OR=1.44, 95%CI: 0.97-2.12). When stratified by race, the significant association was obser ved in neither Asians(Z =1.96, OR =5.63, 95%CI :1.00-31.83) nor Caucasians(Z =0.90, OR=1.12, 95%CI: 0.87-1.45). In the subgroup analysis based on source of controls, there was still significant association in neither the population-based studies(Z =0.13, OR=1.03, 95%CI: 0.71-1.49) nor the hospital-based studies(Z =1.48, OR =2.17, 95%CI : 0.78-6.02). CONCLUSION This meta-analysis supported that there was lack of association between GSTT1 null genotype and laryngeal cancer risk.