慢性鼻-鼻窦炎患者细菌学检测及药敏分析

Distribution and drug sensitivity test of bacteria for patients with chronic rhinosinusitis

目的探讨慢性鼻-鼻窦炎(CRS)患者细菌学分布及药敏分析。方法 63例确诊为CRS的手术患者,取中鼻道脓性分泌物行普通细菌培养,对有临床意义的细菌行药敏试验。结果 63例患者中,43例普通细菌培养结果为阳性,阳性率为68.25%,共分离出细菌15种,排在前3位的是甲型链球菌/黄色奈瑟菌、金黄色葡萄球菌、表皮葡萄球菌。27株行药敏试验,排在前4位的抗生素是环丙沙星81.48%,复方新诺明66.67%,庆大霉素59.26%,左氧氟沙星51.85%。结论对于CRS患者,应根据药敏结果选择抗生素,若未能行药敏试验,应首选喹诺酮类抗生素。

OBJECTIVE To study the distribution and drug sensitivity test of bacteria for patients with chronic rhinosinusitis.METHODS The purulent discharges were collected from middle meatus of 63 patients with chronic rhinosinusitis during sinus surgery.The results of germiculture and drug sensitivity test were analyzed.RESULTS Of the 63 specimens,43(68.25%) showed positive results in germiculture.Of the 15 kinds of bacteria,the first three were alpha streptococcus/Neisseria flava,Staphylococcus aureus and Staphylococcus epidermidis.Of the 27 drug sensitivity tests,the first four antibiotics were ciprofloxacin 81.48%,SMZ-TMP 66.67%,Gentamycin59.26%,and Levofloxacin 51.85%.CONCLUSION For patients with chronic rhinosinusitis,the using of antibiotics should depend on the drug sensitivity test,if we cannot,the fluroquinolones should be recommended.