糖皮质激素口服联合鼓室内注射治疗重度和极重度突发性聋

Combined oral and intratympanic glucocorticoids treatment for severe to profound sudden sensorineural hearing loss

目的观察糖皮质激素全身应用和鼓室内注射联合治疗重度和极重度突发性聋的临床疗效,以探索糖皮质激素治疗突发性聋的方法。方法对54例重度和极重度突发性聋患者的临床资料进行回顾性分析,所有患者均给予口服激素、改善微循环、溶栓抗凝等治疗,同意加用鼓室内注射激素的患者为治疗组,其余患者为对照组,治疗2周后复查纯音测听。结果治疗组和对照组患者平均听阈改善均具有显著统计学意义,但两组之间疗效无差异(P=0.194)。治疗组与对照组中重度突发性聋患者间疗效无差异(P=0.251),两组中极重度突发性聋患者间疗效也无差异(P=0.380)。结论糖皮质激素全身应用联合鼓室内注射治疗重度和极重度突发性聋有效,但并不能得到较单独全身用药更好的疗效。

OBJECTIVE To evaluate the efficacy of combined oral and intratympanic glucocorticoids treatment for severe to profound sudden sensorineural hearing loss(SSNHL).METHODS Fifty-four patients with severe to profound SSNHL were retrospectively studied.They were treated with oral steroids,vasodilators,anticoagulants.The patients who accepted intratympanic methylprednisolone sodium succinate were included the therapy group,the others were included in the control group.Hearing improvements were analyzed respectively after two weeks.RESULTS Hearing in both groups were improved significantly after treatment(P<0.01),but there was no difference in hearing improvements between two groups(P=0.194).The efficacy for severe SSNHL patients in therapy group was equal to those who were in control group(P=0.251),so was the efficacy for profound SSNHL patients in both groups(P=0.380).CONCLUSION The combined systemic and intratympanic glucocorticoids treatment was effective for patients with severe to profound SSNHL,but while with no better efficacy than oral glucocorticoid alone.