局部晚期喉咽鳞状细胞癌紫杉醇+顺铂+氟尿嘧啶方案诱导化疗的近期疗效观察

Effect of TPF induction chemotherapy on locally advanced squamous-cell cancer of hypopharynx

目的观察紫杉醇+顺铂+氟尿嘧啶(TPF)方案诱导化疗对局部晚期喉咽鳞状细胞癌(简称鳞癌)的近期疗效及毒副反应。方法选取2011年1月~2013年10月于本院首次治疗的局部晚期喉咽鳞癌患者78例,采用TPF方案诱导化疗2周期,复查影像学检查,评价疗效。结果全组78例患者共完成156周期化疗,均可评价疗效。其中完全缓解(complete remission,CR)4例(5.1%),部分缓解(partial remission,PR)55例(70.5%),稳定(stable disease,SD)17例(21.8%),进展(progression disease,PD)2例(2.6%)。总有效率(CR+PR)75.6%,Ⅲ/Ⅳ度副反应发生率低。Logistic回归分析显示,有效率与肿瘤中低分化有显著相关性。结论对于局部晚期喉咽鳞癌患者,TPF方案诱导化疗显示了良好的疗效及安全性,可作为局部晚期喉咽癌诱导化疗的选择。同时提示病理分化程度为中低分化的肿瘤患者,更可能从诱导化疗中获益。

OBJECTIVE To observe the short term effects and adverse effects of induction chemotherapy with Paclitaxel,Cisplatin and Fluorouracil(TPF) in locally advanced squamous cell cancer of hypopharynx.METHODS 78 cases locally advanced squamous-cell cancer of hypopharynx formjan 2011 to oct 2013 for the first time treated by TPF scheme,after 2 cycles,to recheck CT scan and evaluate therapeutic effective.RESULTS All 78 cases patients achieved 156 cycles chemotherapy,CR was4 cases(5.1%),PR 55 cases(70.5%),SD 17 cases(21.8%),PD 2 cases(2.6%).Total effective rate(CR+PR) was75.6%,and with low incidence of Ⅲ/Ⅳ grade side effect.Logistic regression analysis shows that there is a significant correlation between effective rate and low differentiation cancer.CONCLUSION For locally advanced squamouscell cancer of hypopharynx patients,the TPF chemotherapy scheme showed good therapeutic effective and safety,could be a choice for the induction chemotherapy treatment in locally advanced squamouscell cancer of hypopharynx.The patients with low differentiation cancer may have benefit from the induction chemotherapy.